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Proton pump inhibitors (PPIs), such as brand names Nexium Prevacid Prilosec

Zegerid, Protonix, AcipHex, Vimovo, are commonly used to reduce acid in the stomach. If you developed chronic kidney disease while on a proton pump inhibitor, or following your taking the drug, and want an attorney in Chicago to help you investigate the possibility of a lawsuit against the maker of the proton pump inhibitor, please contact Chicago based attorney Tom Plouff.

Back in 2014, many lost their cases against AstraZeneca for Nexium causing osteoporosis when the trial judge in decided the plantiff’s expert employed no scientific methodology that would pass rigourous standards under a case called Daubert.

But now, some recent studies may breathe life into cases based on proton pump inhibitors causing chronic kidney disease. These medical studies show an association but whether these studies, or ones to come, establish legal causation remains to be seen.

In a January 2016 article in JAMA Internal Medicine, the lead author, Lazarus, showed an association between Proton pump inhibitors use and a higher risk of incident chronic kidney disease (CKD).

Proton pump inhibitors interfere with the active transport of magnesium, which may cause hypomagnesemia. Chronic Proton pump inhibitors use is associated with increased vascular calcification risk in hemodialysis patients.  Because magnesium acts as inhibitor of calcification, proton pump inhibitors-induced hypomagnesemia may worsen vascular calcifications in patients with CKD.

Proton pump inhibitors are one of the most commonly prescribe medications in the United States. Other observational studies have linked Proton pump inhibitors to serious adverse health outcomes.

There is an association between Proton pump inhibitors use and incident CKD in the general population. The authors note several study limitations, including that participants prescribed proton pump inhibitors may be at higher risk of CKD for reasons unrelated to their proton pump inhibitors use.

Then in April of this year, a study found exposure to proton pump inhibitors, heartburn drugs, is associated with an increased risk of incident CKD CKD progression and end-stage renal disease in the Journal of Nephrology, lead author Yan Xie.  The study shows an association between proton pump inhibitors and acute interstitial nephritis

The findings suggest that long-term use of proton pump inhibitors may be harmful to the kidneys and should be avoided. Proton pump inhibitors use may not only increase the risk of developing chronic kidney disease, but may also increase the risk of its progression to complete kidney failure.


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